LIGAND INDUCED CHEMOTAXIS OF MACROPHAGE CELL LINE U937
نویسندگان
چکیده
منابع مشابه
Growth of Legionella pneumophila in a human macrophage-like (U937) cell line.
We established a model of the bacteria-macrophage interaction to study the cellular basis of Legionella pneumophila pathogenesis and to characterize avirulent L. pneumophila. We found that U937 cells, which are derived from a human histiocytic lymphoma cell line, support intracellular growth of L. pneumophila with a doubling time of 6 h, and that sustained intracellular growth is associated wit...
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BACKGROUND Macrophages play important roles in antitumor immunity, and immunotherapy with the group-specific component protein-derived macrophage-activating factor (GcMAF) has been reported to be effective in patients with various types of cancers. However, in macrophage research, it is important to properly evaluate macrophage activity. MATERIALS AND METHODS U937 macrophages were induced by ...
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OBJECTIVE To examine the interaction between synovial fibroblasts and macrophages in the context of cartilage degradation. METHODS An in vitro model of human cartilage degradation was used, in which purified populations of fibroblasts and macrophages were added to a radiolabeled cartilage disc. Cartilage destruction was measured by the percentage of radiolabel release. RESULTS Fibroblasts, ...
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WSXWS motif is a conserved amino acid sequence that is present in type I cytokine receptors. This motif that can be found both in the ligand binding chains and signal transducer molecule of the receptors with different amino acids at the position "X" plays a role in the receptor folding, ligand binding and signal transduction as well. Structural analysis proved that WSEWS motif of IL-6R is loca...
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ژورنال
عنوان ژورنال: Medical Immunology (Russia)
سال: 2014
ISSN: 2313-741X,1563-0625
DOI: 10.15789/1563-0625-2014-5-443-448